13. The Imbriani Family

Just months after a young, divorced mother of two got involved with a blood drive, she received a call that her marrow matched that of a baby girl with leukemia. At the time, Brook Imbriani had no idea how her selfless donation would impact her own family's life, as well as the life of a sick child. But Brook turned a tragic situation into triumph, and appreciation for her generosity was shown when Extreme Makeover: Home Edition literally knocked the Imbriani's neglected house to the ground and transformed it into a dream home.